Copper-Catalyzed Regiodivergent Borylation of Fluorinated Alkynes and Palladium-Catalyzed Regiospecific Suzuki-Miyaura cross-coupling - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue SYNLETT Année : 2023

Copper-Catalyzed Regiodivergent Borylation of Fluorinated Alkynes and Palladium-Catalyzed Regiospecific Suzuki-Miyaura cross-coupling

Résumé

Alkenylboranes are key intermediates in modern organic synthesis, and they are usually obtained by borylation of alkynes. We report herein a highly regio-and stereoselective syntheses of α,Z-and β,Ztrifluoromethylated-alkenylboranes via copper-catalyzed borylation reactions. Further functionalization by palladium-catalyzed Suzuki-Miyaura crosscoupling have been developed and interestingly a drastic difference of reactivity between α-and β-borylated isomers has been identified.

Domaines

Chimie organique
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Dates et versions

hal-04252372 , version 1 (20-10-2023)

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Citer

Lénaic Rummler, Mariam Abd El Sater, Nicolas Blanchard, Vincent Bizet. Copper-Catalyzed Regiodivergent Borylation of Fluorinated Alkynes and Palladium-Catalyzed Regiospecific Suzuki-Miyaura cross-coupling. SYNLETT, In press, ⟨10.1055/a-2192-6996⟩. ⟨hal-04252372⟩
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