Copper-Catalyzed Regiodivergent Borylation of Fluorinated Alkynes and Palladium-Catalyzed Regiospecific Suzuki-Miyaura cross-coupling
Résumé
Alkenylboranes are key intermediates in modern organic synthesis, and they are usually obtained by borylation of alkynes. We report herein a highly regio-and stereoselective syntheses of α,Z-and β,Ztrifluoromethylated-alkenylboranes via copper-catalyzed borylation reactions. Further functionalization by palladium-catalyzed Suzuki-Miyaura crosscoupling have been developed and interestingly a drastic difference of reactivity between α-and β-borylated isomers has been identified.
Domaines
Chimie organique| Origine | Fichiers produits par l'(les) auteur(s) |
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