The long-term benefit brought in lime-treated soil can be altered by the nature of the surrounding wetting fluid, thus, affecting its durability. However, studies regarding such impact are limited. In this study, the influence of different wetting fluids on the microstructural, physicochemical modifications, and Unconfined Compressive Strength (UCS) evolution of lime-treated soil is investigated. Lime-treated soils are subjected to wetting and drying (W-D) cycles using 0.10 M and 0.60 M NaCl solutions, demineralized water (DW), and Methyl Methacrylate (MMA). The results show that despite the soil being exposed to several W-D cycles, the UCS evolved positively compared to the reference specimen. However, this evolution varied with the types of wetting fluids the specimens were exposed to. The NaCls-and MMA-subjected soil showed an increase in UCS up to about 3 times, while the UCS increase was about 2 times in the corresponding DW-subjected soil. Similarly, the extent of the variation of the final pH and the cumulative calcium concentrations measured in the effluent is marked by the wetting fluids available in the surrounding medium. At the pore structure level, the presence of NaCl solutions and MMA solvent as a wetting fluid was observed to enhance the evolution of pores smaller than 3000 Å. However, such a phenomenon was less significant in the DW-subjected soil. Thus, the study confirms that the type of wetting fluid plays an important role in the evolution of lime-treated soil during the W-D cycles.