Advancing tools for human early lifecourse exposome research and translation (ATHLETE)
Martine Vrijheid
(1, 2)
,
Xavier Basagaña
(1, 2)
,
Juan Gonzalez
(1, 2)
,
Vincent Jaddoe
(3, 4)
,
Genon Jensen
(5)
,
Hector Keun
(6)
,
Rosemary Mceachan
(7)
,
Joana Porcel
(1, 2)
,
Valerie Siroux
(8)
,
Morris Swertz
(9)
,
Cathrine Thomsen
(10)
,
Gunn Marit Aasvang
(10)
,
Sandra Andrušaitytė
(11)
,
Karine Angeli
(12)
,
Demetris Avraam
(13)
,
Ferran Ballester
(14, 15, 16, 17)
,
Paul Burton
(13)
,
Mariona Bustamante
(1, 2)
,
Maribel Casas
(1, 2)
,
Leda Chatzi
(18)
,
Cécile Chevrier
(19)
,
Natacha Cingotti
(5)
,
David Conti
(18)
,
Amélie Crépet
(12)
,
Payam Dadvand
(1, 2)
,
Liesbeth Duijts
(4)
,
Esther van Enckevort
(9)
,
Ana Esplugues
(14, 16, 15)
,
Serena Fossati
(1, 2)
,
Ronan Garlantézec
(20, 19, 21)
,
María Dolores Gómez Roig
(22)
,
Regina Grazuleviciene
(11)
,
Kristine Gützkow
(10)
,
Mònica Guxens
(1, 15, 2, 4)
,
Sido Haakma
(9)
,
Ellen Hessel
(23)
,
Lesley Hoyles
(24)
,
Eleanor Hyde
(9)
,
Jana Klanova
(25)
,
Jacob van Klaveren
(23)
,
Andreas Kortenkamp
(26)
,
Laurent Le Brusquet
(27)
,
Ivonne Leenen
(5)
,
Aitana Lertxundi
(28, 15, 29)
,
Nerea Lertxundi
(28, 29)
,
Christos Lionis
(30)
,
Sabrina Llop
(15, 17)
,
Maria-Jose Lopez-Espinosa
(15, 17, 16)
,
Sarah Lyon-Caen
(8)
,
Lea Maitre
(1, 2)
,
Dan Mason
(7)
,
Sandrine Mathy
(31)
,
Edurne Mazarico
(22)
,
Tim Nawrot
(32, 33)
,
Mark Nieuwenhuijsen
(1, 2)
,
Rodney Ortiz
(1, 2)
,
Marie Pedersen
(34)
,
Josep Perelló
(35)
,
Míriam Pérez-Cruz
(22)
,
Claire Philippat
(8)
,
Pavel Piler
(36)
,
Costanza Pizzi
(37)
,
Joane Quentin
(8)
,
Lorenzo Richiardi
(37)
,
Adrian Rodriguez
(35)
,
Theano Roumeliotaki
(30)
,
José Manuel Sabin Capote
(35)
,
Leonardo Santiago
(35)
,
Susana Santos
(38)
,
Alexandros Siskos
(6)
,
Katrine Strandberg-Larsen
(39)
,
Nikos Stratakis
(1, 18)
,
Jordi Sunyer
(1, 2)
,
Arthur Tenenhaus
(40)
,
Marina Vafeiadi
(30)
,
Rebecca Wilson
(41)
,
John Wright
(7)
,
Tiffany Yang
(7)
,
Remy Slama
(8)
1
ISGlobal -
Instituto de Salud Global - Institute For Global Health [Barcelona]
2 UPF - Universitat Pompeu Fabra [Barcelona]
3 The Generation R Study Group
4 Erasmus MC - Erasmus University Medical Center [Rotterdam]
5 HEAL - Health & Environment Alliance
6 Imperial College London
7 BIHR - Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK
8 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
9 UMCG - University Medical Center Groningen [Groningen]
10 NIPH - Norwegian Institute of Public Health [Oslo]
11 VDU - Vytautas Magnus University - Vytauto Didziojo Universitetas
12 DER - Direction de l'Evaluation des Risques
13 Newcastle University [Newcastle]
14 FISABIO - Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana [Espagne]
15 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
16 UV - Universitat de València
17 Universitat Jaume I = Jaume I University
18 USC - University of Southern California
19 Irset - Institut de recherche en santé, environnement et travail
20 EHESP - École des Hautes Études en Santé Publique [EHESP]
21 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
22 Institut de Recerca Pediàtrica Hospital Sant Joan de Déu [Barcelona, Spain]
23 RIVM - National Institute for Public Health and the Environment [Bilthoven]
24 Nottingham Trent University
25 RECETOX / MUNI - Research Centre for Toxic Compounds in the Environment [Brno]
26 Brunel University London [Uxbridge]
27 NeuroPSI - Institut des Neurosciences Paris-Saclay
28 UPV / EHU - Universidad del País Vasco [Espainia] / Euskal Herriko Unibertsitatea [España] = University of the Basque Country [Spain] = Université du pays basque [Espagne]
29 BioDonostia Health Research Institute = Instituto de Investigación Sanitaria Biodonostia
30 UOC - University of Crete [Heraklion]
31 GAEL - Laboratoire d'Economie Appliquée de Grenoble
32 UHasselt - Hasselt University
33 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
34 UCPH - University of Copenhagen = Københavns Universitet
35 Bettair Cities SL, Barcelona
36 MUNI - Masaryk University [Brno]
37 Department of Oncology [University of Turin]
38 Erasmus University Rotterdam
39 ITU - IT University of Copenhagen
40 L2S - Laboratoire des signaux et systèmes
41 University of Liverpool
2 UPF - Universitat Pompeu Fabra [Barcelona]
3 The Generation R Study Group
4 Erasmus MC - Erasmus University Medical Center [Rotterdam]
5 HEAL - Health & Environment Alliance
6 Imperial College London
7 BIHR - Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK
8 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
9 UMCG - University Medical Center Groningen [Groningen]
10 NIPH - Norwegian Institute of Public Health [Oslo]
11 VDU - Vytautas Magnus University - Vytauto Didziojo Universitetas
12 DER - Direction de l'Evaluation des Risques
13 Newcastle University [Newcastle]
14 FISABIO - Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana [Espagne]
15 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
16 UV - Universitat de València
17 Universitat Jaume I = Jaume I University
18 USC - University of Southern California
19 Irset - Institut de recherche en santé, environnement et travail
20 EHESP - École des Hautes Études en Santé Publique [EHESP]
21 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
22 Institut de Recerca Pediàtrica Hospital Sant Joan de Déu [Barcelona, Spain]
23 RIVM - National Institute for Public Health and the Environment [Bilthoven]
24 Nottingham Trent University
25 RECETOX / MUNI - Research Centre for Toxic Compounds in the Environment [Brno]
26 Brunel University London [Uxbridge]
27 NeuroPSI - Institut des Neurosciences Paris-Saclay
28 UPV / EHU - Universidad del País Vasco [Espainia] / Euskal Herriko Unibertsitatea [España] = University of the Basque Country [Spain] = Université du pays basque [Espagne]
29 BioDonostia Health Research Institute = Instituto de Investigación Sanitaria Biodonostia
30 UOC - University of Crete [Heraklion]
31 GAEL - Laboratoire d'Economie Appliquée de Grenoble
32 UHasselt - Hasselt University
33 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
34 UCPH - University of Copenhagen = Københavns Universitet
35 Bettair Cities SL, Barcelona
36 MUNI - Masaryk University [Brno]
37 Department of Oncology [University of Turin]
38 Erasmus University Rotterdam
39 ITU - IT University of Copenhagen
40 L2S - Laboratoire des signaux et systèmes
41 University of Liverpool
Martine Vrijheid
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- Fonction : Auteur correspondant
- PersonId : 1119492
Connectez-vous pour contacter l'auteur
Karine Angeli
- Fonction : Auteur
- PersonId : 1310665
- IdRef : 15497899X
Ferran Ballester
- Fonction : Auteur
- PersonId : 771699
- ORCID : 0000-0002-6165-3465
Mariona Bustamante
- Fonction : Auteur
- PersonId : 791009
- ORCID : 0000-0003-0127-2860
Cécile Chevrier
- Fonction : Auteur
- PersonId : 1157015
- ORCID : 0000-0003-3101-8222
- IdRef : 095119175
Amélie Crépet
- Fonction : Auteur
- PersonId : 946739
- ORCID : 0000-0002-4603-1211
- IdRef : 130794600
Ana Esplugues
- Fonction : Auteur
Ronan Garlantézec
- Fonction : Auteur
- PersonId : 181840
- IdHAL : ronan-garlantezec
- ORCID : 0000-0001-7420-6341
- IdRef : 115831649
Mònica Guxens
- Fonction : Auteur
- PersonId : 773259
- ORCID : 0000-0002-8624-0333
Lesley Hoyles
- Fonction : Auteur
- PersonId : 764137
- ORCID : 0000-0002-6418-342X
Laurent Le Brusquet
- Fonction : Auteur
- PersonId : 21973
- IdHAL : laurent-le-brusquet
- ORCID : 0000-0001-6930-0886
- IdRef : 201013053
Aitana Lertxundi
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Sandrine Mathy
- Fonction : Auteur
- PersonId : 3562
- IdHAL : sandrine-mathy
- ORCID : 0000-0002-7998-4115
- IdRef : 149600259
Mark Nieuwenhuijsen
- Fonction : Auteur
- PersonId : 759654
- ORCID : 0000-0001-9461-7981
- IdRef : 20063870X
Arthur Tenenhaus
- Fonction : Auteur
- PersonId : 736979
- IdHAL : arthur-tenenhaus
- ORCID : 0000-0003-3459-1518
- IdRef : 115337822
Résumé
Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention. This makes early life a relevant starting point for exposome studies. The Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE) project aims to develop a toolbox of exposome tools and a Europe-wide exposome cohort that will be used to systematically quantify the effects of a wide range of community- and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways, longitudinally from early pregnancy through to adolescence. Exposome tool and data development include as follows: (1) a findable, accessible, interoperable, reusable (FAIR) data infrastructure for early life exposome cohort data, including 16 prospective birth cohorts in 11 European countries; (2) targeted and nontargeted approaches to measure a wide range of environmental exposures (urban, chemical, physical, behavioral, social); (3) advanced statistical and toxicological strategies to analyze complex multidimensional exposome data; (4) estimation of associations between the exposome and early organ development, health trajectories, and biological (metagenomic, metabolomic, epigenetic, aging, and stress) pathways; (5) intervention strategies to improve early life urban and chemical exposomes, co-produced with local communities; and (6) child health impacts and associated costs related to the exposome. Data, tools, and results will be assembled in an openly accessible toolbox, which will provide great opportunities for researchers, policymakers, and other stakeholders, beyond the duration of the project. ATHLETE’s results will help to better understand and prevent health damage from environmental exposures and their mixtures from the earliest parts of the life course onward.
| Origine | Publication financée par une institution |
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