The research work presented in this paper aims to optimize the dynamic response of a carbon-epoxy plate by including into the laminate one frequency-dependent interleaved viscoelastic layer. To keep an acceptable bending stiffness, some holes are created in the viscoelastic layer, thus facilitating the resin through layer penetration during the co-curing manufacturing process. Plates including (or not) one perforated (or non-perforated) viscoelastic layer are manufactured and investigated experimentally and numerically. First, static and dynamic tests are performed on sandwich coupons to characterize the stiffness and damping properties of the plates in a given frequency range. Resulting mechanical properties are then used to set-up a finite element model and simulate the plate dynamic response. In parallel, frequency response measurements are carried out on the manufactured plates, then successfully confronted to the numerical results. Finally, a design of experiments is built based on a limited number on numerical simulations to find the configuration of bridges that maximizes the damping while keeping a stiffness higher than half the stiffness of the equivalent undamped plate.