Affine ind-varieties are infinite dimensional generalizations of algebraic varieties which appear naturally in many different contexts, in particular in the study of automorphism groups of affine spaces. In this article we introduce and develop the basic algebraic theory of topologically integrable derivations of complete topological rings. We establish a bijective algebro-geometric correspondence between additive group actions on affine ind-varieties and topologically integrable derivations of their coordinate pro-rings which extends the classical fruitful correspondence between additive group actions on affine varieties and locally nilpotent derivations of their coordinate rings.