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Pré-Publication, Document De Travail Année : 2020

Calibrated photoacoustic spectrometry with an imaging system

Résumé

Photoacoustic (PA) contrast agents are usually characterized with spectrophotometry or uncalibrated PA imaging systems, leading to partial assessment of their PA efficacy. To perform calibrated PA spectroscopy with a PA imaging system, we developed a method that both corrects for the spectral energy distribution of excitation light and performs a conversion from arbitrary to spectroscopic units, using a reference solution of cupric sulfate. The method was implemented on an imaging setup based on a tunable laser and a 5MHz ultrasound array. We demonstrated robust calibrated spectroscopy on 15µL sample volumes of known chromophores and commonly used PA contrast agents, and for multiple samples simultaneously. The detection was linear with the absorption and the sensitivity below 0.08cm-1.
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Dates et versions

hal-02509232 , version 1 (16-03-2020)
hal-02509232 , version 2 (27-04-2021)
hal-02509232 , version 3 (08-07-2022)
hal-02509232 , version 4 (01-09-2022)

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Mitradeep Sarkar, Gilles Renault, Jérôme Gateau. Calibrated photoacoustic spectrometry with an imaging system. 2020. ⟨hal-02509232v1⟩
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