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Article Dans Une Revue EcoSal Plus Année : 2023

Cell cycle-coordinated maintenance of the Vibrio bipartite genome

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ABSTRACT To preserve the integrity of their genome, bacteria rely on several genome maintenance mechanisms that are co-ordinated with the cell cycle. All members of the Vibrio family have a bipartite genome consisting of a primary chromosome (Chr1) homologous to the single chromosome of other bacteria such as Escherichia coli and a secondary chromosome (Chr2) acquired by a common ancestor as a plasmid. In this review, we present our current understanding of genome maintenance in Vibrio cholerae , which is the best-studied model for bacteria with multi-partite genomes. After a brief overview on the diversity of Vibrio genomic architecture, we describe the specific, common, and co-ordinated mechanisms that control the replication and segregation of the two chromosomes of V. cholerae . Particular attention is given to the unique checkpoint mechanism that synchronizes Chr1 and Chr2 replication.
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hal-04653967 , version 1 (23-07-2024)

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Théophile Niault, Jakub Czarnecki, Morgan Lambérioux, Didier Mazel, Marie-Eve Val. Cell cycle-coordinated maintenance of the Vibrio bipartite genome. EcoSal Plus, 2023, 11 (1), eesp00082022. ⟨10.1128/ecosalplus.esp-0008-2022⟩. ⟨hal-04653967⟩
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