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Article Dans Une Revue (Article De Synthèse) Trends in Analytical Chemistry Année : 2023

Scaling-up metabolomics: Current state and perspectives

Ghina Hajjar
Cécile Canlet
Binta Diémé
Franck Giacomoni
Marie Tremblay-Franco
Fabien Jourdan

Résumé

Metabolomics is now a mature phenotyping tool that provides substantial results within various scientific communities. Its application at large-scale, i.e. on large populations and/or samples, has shown its power for research activities from plant science to human epidemiology and medicine, but it still needs key methodological developments for its routine application. Here, we review the current state of large-scale metabolomics applications, providing recent examples of large cohort studies in human and plant/environment research, and present the remaining scientific challenges of both fields. Then, we address the key common methodological issues, from analytics to data science, to fulfil these objectives and go towards a more comprehensive and interoperable large-scale metabolomics, making it a new key actor in the frame of the One-Health future research.
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Origine : Publication financée par une institution
Licence : CC BY NC ND - Paternité - Pas d'utilisation commerciale - Pas de modification

Dates et versions

hal-04188505 , version 1 (12-09-2023)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

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Citer

Ghina Hajjar, Millena Cristina Barros Santos, Justine Bertrand-Michel, Cécile Canlet, Florence A Castelli, et al.. Scaling-up metabolomics: Current state and perspectives. Trends in Analytical Chemistry, 2023, 167 (20), pp.117225. ⟨10.1016/j.trac.2023.117225⟩. ⟨hal-04188505⟩
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