Cyclic Diaryl λ3-Bromanes: A Rapid Access to Molecular Complexity via Cycloaddition Reactions
Résumé
Biaryls have widespread applications in organic synthesis. However, sequentially polysubstituted biaryls are underdeveloped due to their challenging preparation. Herein, we report the synthesis of unsymmetric 3 3-substituted biaryls via pericyclic reactions of cyclic diaryl 3-bromanes. The functional groups tolerance and atom economy allow access to molecular complexity in a single reaction step. Continuous flow protocol has been designed for the scale-up of the reaction, while post-functionalizations have been developed taking advantage of the residual bromide.
Domaines
ChimieOrigine | Fichiers produits par l'(les) auteur(s) |
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