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Article Dans Une Revue Organic Letters Année : 2021

Cyclic Diaryl λ3-Bromanes: A Rapid Access to Molecular Complexity via Cycloaddition Reactions

Résumé

Biaryls have widespread applications in organic synthesis. However, sequentially polysubstituted biaryls are underdeveloped due to their challenging preparation. Herein, we report the synthesis of unsymmetric 3 3-substituted biaryls via pericyclic reactions of cyclic diaryl  3-bromanes. The functional groups tolerance and atom economy allow access to molecular complexity in a single reaction step. Continuous flow protocol has been designed for the scale-up of the reaction, while post-functionalizations have been developed taking advantage of the residual bromide.

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Chimie
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Dates et versions

hal-03874364 , version 1 (28-11-2022)

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Matteo Lanzi, Racha Abed, Ali Abdine, Maxime de Abreu, Joanna Wencel-Delord. Cyclic Diaryl λ3-Bromanes: A Rapid Access to Molecular Complexity via Cycloaddition Reactions. Organic Letters, 2021, 23 (23), pp.9047-9052. ⟨10.1021/acs.orglett.1c03278⟩. ⟨hal-03874364⟩
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