Directed Palladium Catalyzed C–H (Ethoxycarbonyl)difluoromethylthiolation Reactions.
Résumé
The unprecedented Pd-catalyzed (ethoxycarbonyl)difluoromethylthiolation reaction of various unsaturated derivatives was studied. In the presence of the (ethoxycarbonyl)difluoromethylsulfenamide reagent I and under mild reaction conditions (60 °C), both 2-(hetero)aryl and 2-(a-aryl-vinyl)pyridine derivatives were smoothly functionalized with this methodology (37 examples, up to 87% yield). Moreover, the synthetic interest of this fluorinated moiety was further showcased by its conversion into various original fluorinated residues. Finally, a plausible mechanism for this transformation was suggested.
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Chemistry A European J - 2022 - Doche - Directed Palladium Catalyzed C H Ethoxycarbonyl difluoromethylthiolation Reactions-1.pdf (1.6 Mo)
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