Regioselectivity of the Conjugate Addition of Amines to Dissymmetrical Pull‐Pull Alkenes - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue European Journal of Organic Chemistry Année : 2021

Regioselectivity of the Conjugate Addition of Amines to Dissymmetrical Pull‐Pull Alkenes

Résumé

The regioselectivity of the conjugate nucleophilic addition of amines to vicinal di-acceptor-substituted alkenes has been studied. A set of results obtained with standard primary and secondary amines gives some clues on the relative acceptor character of classical electron-withdrawing groups (EWG). We have shown in addition that computed inverse local nucleophilicity index can be used to predict the regioselectivity of the nucleophilic attack.

Domaines

Chimie
Fichier principal
Vignette du fichier
Regioselectivity - manuscript- EurJOC - CRAC2021.pdf (907.09 Ko) Télécharger le fichier

Dates et versions

hal-03440182 , version 1 (22-11-2021)

Identifiants

Citer

Jacques Maddaluno, Alexander Yu. Rulev, Ilya N Zubkov, Igor A Ushakov, Valentin A Semenov, et al.. Regioselectivity of the Conjugate Addition of Amines to Dissymmetrical Pull‐Pull Alkenes. European Journal of Organic Chemistry, 2021, 2021 (22), pp.3278 - 3288. ⟨10.1002/ejoc.202100325⟩. ⟨hal-03440182⟩
34 Consultations
90 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More