Regioselectivity of the Conjugate Addition of Amines to Dissymmetrical Pull‐Pull Alkenes
Résumé
The regioselectivity of the conjugate nucleophilic addition of amines to vicinal di-acceptor-substituted alkenes has been studied. A set of results obtained with standard primary and secondary amines gives some clues on the relative acceptor character of classical electron-withdrawing groups (EWG). We have shown in addition that computed inverse local nucleophilicity index can be used to predict the regioselectivity of the nucleophilic attack.
Domaines
Chimie
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Regioselectivity - manuscript- EurJOC - CRAC2021.pdf (907.09 Ko)
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