Calcium-independent disruption of microtubule growth following nanosecond pulsed electric field exposure in U87 human glioblastoma cells
Résumé
High powered, nanosecond duration pulsed electric
fields (nsPEF) have been proposed as a minimal side-effect,
electrical cancer therapy, unlikely to result in resistance.
They induce apoptotic death in cancerous cells and reduce
tumour size by a currently unknown mechanism [1,2].
Microtubule depolymerisation is an intrinsic, early
event in normally occurring apoptosis and electric fields
have been shown to disrupt microtubule polymerisation
[3,4]. Given this, it is therefore possible that nsPEF cause
microtubule depolymerisation, which initiates apoptosis.
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