Communication Dans Un Congrès Année : 2015

Calcium-independent disruption of microtubule growth following nanosecond pulsed electric field exposure in U87 human glioblastoma cells

Sylvia M. Bardet
Malak Soueid
  • Fonction : Auteur
Delia Arnaud-Cormos
Philippe Lévêque
Rodney O'Connor
  • Fonction : Auteur

Résumé

High powered, nanosecond duration pulsed electric fields (nsPEF) have been proposed as a minimal side-effect, electrical cancer therapy, unlikely to result in resistance. They induce apoptotic death in cancerous cells and reduce tumour size by a currently unknown mechanism [1,2]. Microtubule depolymerisation is an intrinsic, early event in normally occurring apoptosis and electric fields have been shown to disrupt microtubule polymerisation [3,4]. Given this, it is therefore possible that nsPEF cause microtubule depolymerisation, which initiates apoptosis.

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hal-02469230 , version 1 (17-11-2020)

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  • HAL Id : hal-02469230 , version 1

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Lynn Carr, Sylvia M. Bardet, Malak Soueid, Delia Arnaud-Cormos, Philippe Lévêque, et al.. Calcium-independent disruption of microtubule growth following nanosecond pulsed electric field exposure in U87 human glioblastoma cells. EBTT WORKSHOP 2015, 2015, Ljubljana, Slovenia. ⟨hal-02469230⟩
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