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Article Dans Une Revue Rapid Communications in Mass Spectrometry Année : 2019

Increasing specificity of tandem mass spectrometry by laser‐induced dissociation

Résumé

Mass spectrometry offers an arsenal of tools for diverse proteomic investigations. This perspective article reviews some of the recent developments in the field of coupling laser‐induced dissociation with mass spectrometry (LID‐MS). Strategies involving labelling with a chromophore to induce specific photo‐absorption properties are considered, with a focus on specific amino acid derivatization. Some of the opportunities and challenges of LID‐MS after targeted labelling for increasing specificity in complex sample analysis are discussed.
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Dates et versions

hal-02389133 , version 1 (04-09-2020)

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Marion Girod. Increasing specificity of tandem mass spectrometry by laser‐induced dissociation. Rapid Communications in Mass Spectrometry, 2019, Perspectives on the future of Mass Spectrometry, 33 (S3), pp.64-71. ⟨10.1002/rcm.8148⟩. ⟨hal-02389133⟩
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