Increasing specificity of tandem mass spectrometry by laser‐induced dissociation
Résumé
Mass spectrometry offers an arsenal of tools for diverse proteomic investigations. This perspective article reviews some of the recent developments in the field of coupling laser‐induced dissociation with mass spectrometry (LID‐MS). Strategies involving labelling with a chromophore to induce specific photo‐absorption properties are considered, with a focus on specific amino acid derivatization. Some of the opportunities and challenges of LID‐MS after targeted labelling for increasing specificity in complex sample analysis are discussed.
Domaines
Chimie analytique
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2019-RapidComMassSpectro-Girod-IncreasingSpecificityTandem MassSpectroLID.pdf (3.17 Mo)
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