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Article Dans Une Revue Drug Discovery Today Biosilico Année : 2019

Exploration of biomedical dendrimer space based on in-vitro physicochemical parameters: key factor analysis (Part 1)

Résumé

Dendrimers are highly branched, star-shaped macromolecules with nanometer-scale dimensions that can be readily modified with a range of functional groups, thus modifying their physicochemical and biological properties. In nanomedicine, dendrimers can be used as vectors for the targeted delivery strategy of a variety of biologically active agents or can be used as drug per se. In the future, it will be necessary to designate and develop ‘safe’ dendrimers, which is currently a crucial concern. Here, we analyze the key in vitro physicochemical parameters to be considered for preclinical evaluation of biomedical dendrimers.
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hal-02334985 , version 1 (22-10-2021)

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Serge Mignani, João Rodrigues, Rene Roy, Xiangyang Shi, Valentin Ceña, et al.. Exploration of biomedical dendrimer space based on in-vitro physicochemical parameters: key factor analysis (Part 1). Drug Discovery Today Biosilico, 2019, 24 (5), pp.1176-1183. ⟨10.1016/j.drudis.2019.02.014⟩. ⟨hal-02334985⟩
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