Exploration of biomedical dendrimer space based on in-vitro physicochemical parameters: key factor analysis (Part 1)
Résumé
Dendrimers are highly branched, star-shaped macromolecules with nanometer-scale dimensions that can be readily modified with a range of functional groups, thus modifying their physicochemical and biological properties. In nanomedicine, dendrimers can be used as vectors for the targeted delivery strategy of a variety of biologically active agents or can be used as drug per se. In the future, it will be necessary to designate and develop ‘safe’ dendrimers, which is currently a crucial concern. Here, we analyze the key in vitro physicochemical parameters to be considered for preclinical evaluation of biomedical dendrimers.
Domaines
Chimie de coordination| Origine | Fichiers produits par l'(les) auteur(s) |
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