Validation of 4D-flow-based pressure difference estimators
Résumé
Purpose: The pressure difference across stenotic blood vessels serves as an important clinical index for the diagnosis of many cardiovascular diseases. While the clinical gold standard for pressure difference measurements is invasive catheterization, Phase-Contrast Magnetic Resonance Imaging is a promising tool for enabling a non-invasive quantification, by linking highly spatially resolved velocity measurements with pressure differences via the incompressible Navier-Stokes equations. In this work we provide a validation with phantom and patient data of pressure difference maps estimators. Methods: We compare the classical Pressure Poisson Estimator (PPE) and the new Stokes Estimator (STE) against catheter pressure measurements under a large variety of flow regimes. We include several phantom data sets with different anatomic and hemodynamic severities. We also include two patient data sets. Results: The STE shows always considerably more accuracy than the PPE. Both PPE and STE methods are sensitive to the lumen segmentation, with the STE the less sensitive of both. Conclusion: The STE appears to be more accurate (compared to catheterization) and more robust to lumen segmentation than the PPE confirming reported findings from numerical experiments.
Domaines
Imagerie
Origine : Fichiers produits par l'(les) auteur(s)
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