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Pré-Publication, Document De Travail Année : 2020

Validation of 4D flow based relative pressure maps in aortic flows

Résumé

While the clinical gold standard for pressure difference measurements is invasive catheterization, 4D Flow MRI is a promising tool for enabling a non-invasive quantification, by linking highly spatially resolved velocity measurements with pressure differences via the incompressible Navier--Stokes equations. In this work we provide a validation and comparison with phantom and clinical patient data of pressure difference maps estimators. We compare the classical Pressure Poisson Estimator (PPE) and the new Stokes Estimator (STE) against catheter pressure measurements under a variety of stenosis severities and flow intensities. Since it is the clinical range of interest and Reynolds stress measurements in 4D Flow MRI are only feasible in controlled experimental settings, we perform the validation on standard clinical 4D Flow data, and therefore on laminar flows and pressure gradients. However, we also show the limits of such methods on transitional flow. Specifically, we use several 4D Flow data sets of realistic aortic phantoms with different anatomic and hemodynamic severities and two patients with aortic coarctation. In all cases, the STE method yields more accurate results than the PPE method compared to catheterization data. The results indicate an improved robustness of the STE method with respect to variation in lumen segmentation. The superiority of the STE becomes more evident when increasing the Reynolds number, hence being able to better capture pressure gradients when moving to transitional flow regimes.

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Dates et versions

hal-02113750 , version 1 (29-04-2019)
hal-02113750 , version 2 (07-07-2020)
hal-02113750 , version 3 (28-10-2020)

Identifiants

  • HAL Id : hal-02113750 , version 3

Citer

David Nolte, Jesús Urbina, Julio Sotelo, Leo Sok, Cristian Montalba, et al.. Validation of 4D flow based relative pressure maps in aortic flows. 2020. ⟨hal-02113750v3⟩
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