Whole-brain high-resolution structural connectome: inter-subject validation and application to the anatomical segmentation of the striatum - Archive ouverte HAL Access content directly
Journal Articles Brain Topography: a Journal of Cerebral Function and Dynamics Year : 2017

Whole-brain high-resolution structural connectome: inter-subject validation and application to the anatomical segmentation of the striatum

Abstract

The present study describes extraction of high-resolution structural connectome (HRSC) in 99 healthy subjects, acquired and made available by the Human Connectome Project. Single subject connectomes were then registered to the common surface space to allow assessment of inter-individual reproducibility of this novel technique using a leave-one-out approach. The anatomic relevance of the surface-based connectome was examined via a clustering algorithm, which identified anatomic subdivisions within the striatum. The connectivity of these striatal subdivisions were then mapped on the cortical and other subcortical surfaces. Findings demonstrate that HRSC analysis is robust across individuals and accurately models the actual underlying brain networks related to the striatum. This suggests that this method has the potential to model and characterize the healthy whole-brain structural network at high anatomic resolution.
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hal-01657960 , version 1 (07-12-2017)

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Pierre Besson, Nicolas Carrière, Sarah Kathleen Bandt, Marc Tommasi, Xavier Leclerc, et al.. Whole-brain high-resolution structural connectome: inter-subject validation and application to the anatomical segmentation of the striatum. Brain Topography: a Journal of Cerebral Function and Dynamics, 2017, 30 (3), pp.291-302. ⟨10.1007/s10548-017-0548-0⟩. ⟨hal-01657960⟩
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