Model of cell damage in single session radiation treatments based on continuous-time Markov chains - Archive ouverte HAL
Communication Dans Un Congrès Année : 2012

Model of cell damage in single session radiation treatments based on continuous-time Markov chains

Résumé

A new continuous-time statistical model for modelling the effect of radiotherapy treatment is proposed. In contrast with classical models, it takes in account heterogeneity of cell damage and repair. In this paper, a bi-scale continuous-time model is derived to describe tumor and normal tissue lifespans. We show that the cell lifespan can be described by a continuous-time Markov model. The tumor control probabilities and normal tissue complication probabilities are expressed. The model has been implemented into Matlab and numerical simulations have emphasised the effects of the model parameters on the model output.
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Dates et versions

hal-00762658 , version 1 (07-12-2012)

Identifiants

Citer

Roukaya Keinj, Magalie Thomassin, Thierry Thierry Bastogne, Pierre Vallois. Model of cell damage in single session radiation treatments based on continuous-time Markov chains. 8th IFAC Symposium on Biological and Medical Systems BMS 2012, Aug 2012, Budapest, Hungary. pp.160-165, ⟨10.3182/20120829-3-HU-2029.00081⟩. ⟨hal-00762658⟩
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