In this paper, we focus on the performances optimization of a power stages for a nomadic transmitter front-end for multi-radio applications. Performance of such a front-end are to guarantee efficiency (peak and average) whatever the modulation scheme, carrier frequency and bandwidth are. Herein, we delimited the case of study to two band of interest: LTE (2-2.2 GHz) and WiMAX (3.6-3.8 GHz), and designed a dual-band PA. The PA operates in class E, in order to preserve the efficiency. The idea is to demonstrate the ability to amplify amplitude modulated signal and/or control the mean power of the signal by supply and driving signal variations, at the both frequency bands expected. Results show the possibility to efficiently amplify modulated signal or to adapt to mean power variations on the two bands. These new results allow to reconsider the transmitter architectures design approaches.