There are great challenges in biological research to study mechanical or chemical interactions between biological objects and artificial parts, to analyse the biocompatibility of artificial materials and/or to increase knowledge about biological cells. Some interaction studies between cells and artificial objects require to positioning very small objects whose typical size is comparable with cell's size (typically 5-20 micrometers). This paper presents design, building and testing of a new micro-manipulation station able to grasp, transport and release ten micrometers objects. Devoted to an existing piezoelectric microgripper, innovative end-effectors in silicon have been designed after several mechanical studies. They have been built with microfabrication processes (DRIE1) in SOI 2 wafers. For the application, the positioning of silicate crystals which contain iron close to E-Coli bacteria, new end-effectors were glued on the piezoelectric microgripper. Mounted on a three axis micropositioning stage under a videomicroscope, this innovative microgripper is able to grasp a silicate crystal of 15 micrometers in the aire and release it in the bacteria liquid medium.