The accurate simulation of the dynamics of polydisperse evaporating sprays in unsteady gaseous flow with large scale vortical structures is both a crucial issue for industrial combustion application and a challenge for modelling and scientific computing. Various appraoches have been developped in order to resolve the dispersed liquid phase starting from a “mesoscopic” level of description through the Williams equation. The usual Lagrangian approaches in polydisperse unsteady configurations lead to a very high computational cost and induce coupling difficulties due to the different type of description of the two phases involved. Several Eulerian models have been recently developed in order to avoid these two difficulties. However, the validation of the obtained models through detailed comparisons with measurements on well-instrumented experimental devices are seldom conducted in the litterature. In the present contribution, we consider the configuration of acoustically pulsated free jets with a polydisperse spray injection in a 2D axisymmetrical pulsated jet. It creates large vortical structure which are representative of the flow in more complex configurations and a strong interaction with the injected spray. In this context, we provide both a series of detailed experimental measurements through the coupling of laser diagnostics, as well as the multi-fluid modelling and associated numerical schemes in order to simulate accurately the dynamics of the spray. It allows us to study the physics of the coupling between the two phases and to validate the Eulerian multi-fluid model using the experimental measurements.