A solution to the component instability problem in the preparation of peptides containing C2 substituted cis-cyclobutane b-aminoacids: synthesis of a stable rhodopeptin analogue.
Résumé
Despite the inherent instability of C2-substituted cis-cyclobutane β-aminoacids, incorporation of such residues into peptides is shown to be possible through use of a 1-amino-2-(hydroxymethyl)cyclobutane derivative as a stable β-aminoacid surrogate. This synthetic strategy was validated by the synthesis of a rhodopeptin analogue.
Domaines
Chimie organique| Origine | Fichiers produits par l'(les) auteur(s) |
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