A solution to the component instability problem in the preparation of peptides containing C2 substituted cis-cyclobutane b-aminoacids: synthesis of a stable rhodopeptin analogue. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Tetrahedron Letters Année : 2006

A solution to the component instability problem in the preparation of peptides containing C2 substituted cis-cyclobutane b-aminoacids: synthesis of a stable rhodopeptin analogue.

Résumé

Despite the inherent instability of C2-substituted cis-cyclobutane β-aminoacids, incorporation of such residues into peptides is shown to be possible through use of a 1-amino-2-(hydroxymethyl)cyclobutane derivative as a stable β-aminoacid surrogate. This synthetic strategy was validated by the synthesis of a rhodopeptin analogue.

Domaines

Chimie organique
Fichier principal
Vignette du fichier
TL2006-2.pdf (437.83 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-00118385 , version 1 (16-02-2007)

Identifiants

Citer

Olivier Roy, Sophie Faure, David J Aitken. A solution to the component instability problem in the preparation of peptides containing C2 substituted cis-cyclobutane b-aminoacids: synthesis of a stable rhodopeptin analogue.. Tetrahedron Letters, 2006, 47, pp.5981-5984. ⟨10.1016/j.tetlet.2006.06.027⟩. ⟨hal-00118385⟩
60 Consultations
89 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More