In the first chapter of this manuscript, my previous research projects are firstly synthesized. Based on the current context of musculoskeletal disorders which are considered as a critical public health issue, a conceptual five-step model for physical ergonomics is introduced (Model, Sensor, Analysis, Assessment, Intervention). This model serves as a basis for the first part of my previous research projects dedicated to physical ergonomic assessment using on-body sensors (electrogoniometers, inertial measurement units, etc.). As this assessment is also feasible in real-time, the second part of my previous research is submitted, by focusing on the use of continuous sensorial feedback, so called biofeedback, for human motion optimization. In a third part, the ergonomic intervention is presented in terms of physical assistance, by considering exoskeletons as a promising solution to prevent musculoskeletal disorders. The analysis of human-exoskeleton interactions thus allows to limit current issues and extents related to the use of these disposals. In the second chapter of this manuscript, the five-step model for physical ergonomics permits to lay the foundation of my future research projects. These projects are including investigations on new methodologies for characterizing human motion, e.g. mecanomyography and embedded force sensors, both in sport and occupational environments. Developing methodologies for assessing passive exoskeletons in the field is also explored, as well as the improvement of human-exoskeleton interactions, which will allow forward definition of bioinspired control laws for active exoskeletons. These future projects are based on collaborations with both academic and professional partners. Finally, the last chapter of this manuscript summarizes my academic activities and responsibilities, both at scientific level through publications and research grants, and pedagogical level through education initiatives and innovative pedagogical projects that have been funded.