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Article Dans Une Revue Environmental Pollution Année : 2011

Uranium bioaccumulation and biological disorders induced in zebrafish (Danio rerio) after a depleted uranium waterborne exposure

Résumé

Because of its toxicity and its ubiquity within aquatic compartments, uranium (U) represents a significant hazard to aquatic species such as fish. In a previous study, we investigated some biological responses in zebrafish either exposed to depleted or to enriched U (i.e., to different radiological activities). However, results required further experiments to better understand biological responses. Moreover, we failed to clearly demonstrate a significant relationship between biological effects and U radiological activity. We therefore chose to herein examine U bioaccumulation and induced effects in zebrafish according to a chemical dose-response approach. Results showed that U is highly bioconcentrated in fish, according to a time- and concentration-dependent model. Additionally, hepatic antioxidant defenses, red blood cells DNA integrity and brain acetylcholinesterase activity were found to be significantly altered. Generally, the higher the U concentration, the sooner and/or the greater the effect, suggesting a close relationship between accumulation and effect.

Dates et versions

halsde-00578760 , version 1 (22-03-2011)

Identifiants

Citer

Sabrina Barillet, Christelle Adam-Guillermin, Olivier Palluel, Jean-Marc Porcher, Alain Devaux. Uranium bioaccumulation and biological disorders induced in zebrafish (Danio rerio) after a depleted uranium waterborne exposure. Environmental Pollution, 2011, 159 (2), pp.495-502. ⟨10.1016/j.envpol.2010.10.013⟩. ⟨halsde-00578760⟩
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