Article Dans Une Revue Blood Année : 2014

TNF-mediated inflammation represses GATA1 and activates p38 MAP kinase in RPS19-deficient hematopoietic progenitors

Elena Bibikova
  • Fonction : Auteur
Min-Young Youn
  • Fonction : Auteur
Nadia Danilova
  • Fonction : Auteur
Yukako Ono-Uruga
  • Fonction : Auteur
Yoan Konto-Ghiorghi
Rachel Ochoa
  • Fonction : Auteur
Anupama Narla
  • Fonction : Auteur
Bertil Glader
  • Fonction : Auteur
Shuo Lin
  • Fonction : Auteur
Kathleen M Sakamoto
  • Fonction : Auteur

Résumé

Diamond-Blackfan anemia (DBA) is an inherited disorder characterized by defects in erythropoiesis, congenital abnormalities, and predisposition to cancer. Approximately 25% of DBA patients have a mutation in RPS19, which encodes a component of the 40S ribosomal subunit. Upregulation of p53 contributes to the pathogenesis of DBA, but the link between ribosomal protein mutations and erythropoietic defects is not well understood. We found that RPS19 deficiency in hematopoietic progenitor cells leads to decreased GATA1 expression in the erythroid progenitor population and p53-dependent upregulation of tumor necrosis factor-a (TNF-a) in nonerythroid cells. The decrease in GATA1 expression was mediated, at least in part, by activation of p38 MAPK in erythroid cells and rescued by inhibition of TNF-a or p53. The anemia phenotype in rps19-deficient zebrafish was reversed by treatment with the TNF-a inhibitor etanercept. Our data reveal that RPS19 deficiency leads to inflammation, p53-dependent increase in TNF-a, activation of p38 MAPK, and decreased GATA1 expression, suggesting a novel mechanism for the erythroid defects observed in DBA

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hal-05534615 , version 1 (03-03-2026)

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Elena Bibikova, Min-Young Youn, Nadia Danilova, Yukako Ono-Uruga, Yoan Konto-Ghiorghi, et al.. TNF-mediated inflammation represses GATA1 and activates p38 MAP kinase in RPS19-deficient hematopoietic progenitors. Blood, 2014, 124 (25), pp.3791-3798. ⟨10.1182/blood-2014-06-584656⟩. ⟨hal-05534615⟩
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