<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-05534615</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-04-25T15:39:19+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">TNF-mediated inflammation represses GATA1 and activates p38 MAP kinase in RPS19-deficient hematopoietic progenitors</title>
            <author role="aut">
              <persName>
                <forename type="first">Elena</forename>
                <surname>Bibikova</surname>
              </persName>
              <idno type="halauthorid">4054844-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Min-Young</forename>
                <surname>Youn</surname>
              </persName>
              <idno type="halauthorid">4054845-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nadia</forename>
                <surname>Danilova</surname>
              </persName>
              <idno type="halauthorid">4054846-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yukako</forename>
                <surname>Ono-Uruga</surname>
              </persName>
              <idno type="halauthorid">4054847-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yoan</forename>
                <surname>Konto-Ghiorghi</surname>
              </persName>
              <email type="md5">c01915d6518b2fab516345ce6e754475</email>
              <email type="domain">univ-rouen.fr</email>
              <idno type="idhal" notation="string">yoan-konto-ghiorghi</idno>
              <idno type="idhal" notation="numeric">179652</idno>
              <idno type="halauthorid" notation="string">27795-179652</idno>
              <idno type="IDREF">https://www.idref.fr/140865691</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9444-1322</idno>
              <affiliation ref="#struct-73500"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Rachel</forename>
                <surname>Ochoa</surname>
              </persName>
              <idno type="halauthorid">4054848-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anupama</forename>
                <surname>Narla</surname>
              </persName>
              <idno type="halauthorid">1682864-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bertil</forename>
                <surname>Glader</surname>
              </persName>
              <idno type="halauthorid">574165-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Shuo</forename>
                <surname>Lin</surname>
              </persName>
              <idno type="halauthorid">214795-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Kathleen</forename>
                <forename type="middle">M</forename>
                <surname>Sakamoto</surname>
              </persName>
              <idno type="halauthorid">4054849-0</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Yoan</forename>
                <surname>KONTO-GHIORGHI</surname>
              </persName>
              <email type="md5">c01915d6518b2fab516345ce6e754475</email>
              <email type="domain">univ-rouen.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2026-03-03 13:22:13</date>
              <date type="whenModified">2026-03-25 12:14:02</date>
              <date type="whenReleased">2026-03-03 13:43:41</date>
              <date type="whenProduced">2014-12-11</date>
              <date type="whenEndEmbargoed">2026-03-03</date>
              <ref type="file" target="https://hal.science/hal-05534615v1/document">
                <date notBefore="2026-03-03"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-05534615v1/file/Bibikova--TNF-mediated%20inflamm.pdf" id="file-5534615-4737996">
                <date notBefore="2026-03-03"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="674523">
                <persName>
                  <forename>Yoan</forename>
                  <surname>KONTO-GHIORGHI</surname>
                </persName>
                <email type="md5">c01915d6518b2fab516345ce6e754475</email>
                <email type="domain">univ-rouen.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-05534615</idno>
            <idno type="halUri">https://hal.science/hal-05534615</idno>
            <idno type="halBibtex">bibikova:hal-05534615</idno>
            <idno type="halRefHtml">&lt;i&gt;Blood&lt;/i&gt;, 2014, 124 (25), pp.3791-3798. &lt;a target="_blank" href="https://dx.doi.org/10.1182/blood-2014-06-584656"&gt;&amp;#x27E8;10.1182/blood-2014-06-584656&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Blood, 2014, 124 (25), pp.3791-3798. &amp;#x27E8;10.1182/blood-2014-06-584656&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://hal.science/licences/copyright/">Copyright - All rights reserved<ref corresp="#file-5534615-4737996"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt/>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">TNF-mediated inflammation represses GATA1 and activates p38 MAP kinase in RPS19-deficient hematopoietic progenitors</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Elena</forename>
                    <surname>Bibikova</surname>
                  </persName>
                  <idno type="halauthorid">4054844-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Min-Young</forename>
                    <surname>Youn</surname>
                  </persName>
                  <idno type="halauthorid">4054845-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nadia</forename>
                    <surname>Danilova</surname>
                  </persName>
                  <idno type="halauthorid">4054846-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yukako</forename>
                    <surname>Ono-Uruga</surname>
                  </persName>
                  <idno type="halauthorid">4054847-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yoan</forename>
                    <surname>Konto-Ghiorghi</surname>
                  </persName>
                  <email type="md5">c01915d6518b2fab516345ce6e754475</email>
                  <email type="domain">univ-rouen.fr</email>
                  <idno type="idhal" notation="string">yoan-konto-ghiorghi</idno>
                  <idno type="idhal" notation="numeric">179652</idno>
                  <idno type="halauthorid" notation="string">27795-179652</idno>
                  <idno type="IDREF">https://www.idref.fr/140865691</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9444-1322</idno>
                  <affiliation ref="#struct-73500"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Rachel</forename>
                    <surname>Ochoa</surname>
                  </persName>
                  <idno type="halauthorid">4054848-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anupama</forename>
                    <surname>Narla</surname>
                  </persName>
                  <idno type="halauthorid">1682864-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bertil</forename>
                    <surname>Glader</surname>
                  </persName>
                  <idno type="halauthorid">574165-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Shuo</forename>
                    <surname>Lin</surname>
                  </persName>
                  <idno type="halauthorid">214795-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Kathleen</forename>
                    <forename type="middle">M</forename>
                    <surname>Sakamoto</surname>
                  </persName>
                  <idno type="halauthorid">4054849-0</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">11250</idno>
                <idno type="issn">0006-4971</idno>
                <idno type="eissn">1528-0020</idno>
                <title level="j">Blood</title>
                <imprint>
                  <publisher>American Society of Hematology</publisher>
                  <biblScope unit="volume">124</biblScope>
                  <biblScope unit="issue">25</biblScope>
                  <biblScope unit="pp">3791-3798</biblScope>
                  <date type="datePub">2014-12-11</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1182/blood-2014-06-584656</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.mhep.hem">Life Sciences [q-bio]/Human health and pathology/Hematology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Diamond-Blackfan anemia (DBA) is an inherited disorder characterized by defects in erythropoiesis, congenital abnormalities, and predisposition to cancer. Approximately 25% of DBA patients have a mutation in RPS19, which encodes a component of the 40S ribosomal subunit. Upregulation of p53 contributes to the pathogenesis of DBA, but the link between ribosomal protein mutations and erythropoietic defects is not well understood. We found that RPS19 deficiency in hematopoietic progenitor cells leads to decreased GATA1 expression in the erythroid progenitor population and p53-dependent upregulation of tumor necrosis factor-a (TNF-a) in nonerythroid cells. The decrease in GATA1 expression was mediated, at least in part, by activation of p38 MAPK in erythroid cells and rescued by inhibition of TNF-a or p53. The anemia phenotype in rps19-deficient zebrafish was reversed by treatment with the TNF-a inhibitor etanercept. Our data reveal that RPS19 deficiency leads to inflammation, p53-dependent increase in TNF-a, activation of p38 MAPK, and decreased GATA1 expression, suggesting a novel mechanism for the erythroid defects observed in DBA</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="regroupinstitution" xml:id="struct-73500" status="VALID">
          <idno type="ROR">https://ror.org/00f54p054</idno>
          <orgName>Stanford University</orgName>
          <desc>
            <address>
              <addrLine>450 Serra Mall, Stanford, CA 94305-2004</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">https://www.stanford.edu/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>