Microdosimetry and Radiolytic Species Production at Ultra-High- Dose Rates with GATE 10.
2 SUBATECH - Laboratoire de physique subatomique et des technologies associées
3 LP2I - Bordeaux - Laboratoire de Physique des Deux Infinis Bordeaux
4 UNICANCER/ICO - Institut de Cancérologie de l'Ouest [Angers/Nantes]
5 GIP ARRONAX - GIP ARRONAX [Nantes]
6 IMT Atlantique - IMT Atlantique
7 US2B - Unité en Sciences Biologiques et Biotechnologies de Nantes
8 IMN - Institut des Matériaux de Nantes Jean Rouxel
9 INC-CNRS - Institut de Chimie - CNRS Chimie
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Résumé
Background: It has been observed that ultra-high dose rate radiation therapy could minimize normal tissue toxicity without compromising tumor control. Despite its potential benefits, the underlying mechanism of Flash effect remains indistinct. In this study, we propose to evaluate the evolution of species till long-time post-irradiation. Material and Methods: In this study, we used the new GATE platform (version 10), implementing for the first time, all Geant4-DNA chemistry constructors. We simulated a 67.5 MeV proton beam (ARRONAX beam facility, Nantes, France) at ultra-high dose rate (between 0.2 Gy/s and 60 kGy/s) to irradiate ultra-pure liquid water sample in the plateau region of the Bragg peak. We calculated the evolution of reactive species yields along time till one-hour post-irradiation and investigated the influence of oxygen concentrations and pH variations for different dose rates to compare with measurements. Preliminary results: In GATE 10, we proposed and tested the implementation of different pulses duration. Then, simulated yields for H2O2, eaq− and O2*− species, one-hour post-irradiation, were compared with measurements. To go further, we estimated radiation-induced DNA damage: single strand breaks (SSB) and double strand breaks (DSB) to compare with measurements for endothelial cells (HUVEC) and Human Pericytes from Placenta (hPC-PL).