AOP in the context of radioecology: challenges and insights - Archive ouverte HAL
Communication Dans Un Congrès Année : 2024

AOP in the context of radioecology: challenges and insights

L'AOP dans le contexte de la radioécologie: défis et perspectives

Résumé

The definition of reference levels for radiological protection of the environment is dependent on the methodologies and applicability domains considered by the relevant expert groups (ICRP, IAEA, ERICA European Consortium). However, these methodologies share common limitations regarding the derived reference levels, mainly due to the use of available data, coming from laboratory experiments with the observation of biological endpoints that are not necessarily representative of the wildlife chronically exposed to various sources and levels of ionising radiation. Furthermore, the potential presence of other pollutants and stressors (abiotic parameters, etc) that interact with radionuclides makes it challenging to assess the risk to wildlife in realistic exposure scenarios. The Adverse Outcome Pathways (AOP) framework appears to be a valuable tool that helps to structure a sequence of causally linked events at different biological levels (Molecular Initiating Event, Key Events (KE), and Adverse Outcome (AO)). In the context of ecological risk assessment, AOP provide a way of linking molecular data, usually obtained in laboratory conditions, to ecological levels, i.e., community and ecosystem, for which the definition of relevant key events is still challenging. In addition, AOP networks can be proposed to help to compare effects between different types of stressors; to deconvolute biological effects in the context of exposures to multiple stressors. AOP provides an efficient summary of existing data through a clear and standardized framework accessible via the open access database AOP-KB, shared by research and regulators communities. This work proposes a review of the challenges of developing AOP for radioecology. A few guidelines are proposed to overcome some of the identified challenges. These include the assessment of possible relevant ecological endpoints regarding ionising radiation for AOP development, proposal of integrated and multidisciplinary approaches to fuel AOP development, and discussions of AOP applications to inform ecological risk assessment.
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hal-04867931 , version 1 (06-01-2025)

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  • HAL Id : hal-04867931 , version 1

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Elizabeth Dufourcq-Sekatcheff, Loic Quevarec, Marie-Laure Delignette-Muller, Clément Car, Jean-Marc Bonzom, et al.. AOP in the context of radioecology: challenges and insights. ERPW2024 - European radiation protection week, European Radiation Research Platforms (MEENAS); Istituto Superiore di Sanità (ISS); Italian Association of Radiation Protection (AIRP), Nov 2024, Rome, Italy. ⟨hal-04867931⟩
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