Article Dans Une Revue Neurology Année : 2024

Progressive Cerebrocerebellar Uncoupling in Sporadic and Genetic Forms of Amyotrophic Lateral Sclerosis

Marlene Tahedl
  • Fonction : Auteur
Ee Ling Tan
  • Fonction : Auteur
Jana Kleinerova
  • Fonction : Auteur
Siobhan Delaney
  • Fonction : Auteur
Jennifer Hengeveld
Mark Doherty
Russell Mclaughlin
Pierre-Francois Pradat
  • Fonction : Auteur
Orla Hardiman
Kai Ming Chang
  • Fonction : Auteur
Jasmin Lope
  • Fonction : Auteur
Peter Bede
  • Fonction : Auteur

Résumé

Amyotrophic lateral sclerosis (ALS) is predominantly associated with motor cortex, corticospinal tract (CST), brainstem, and spinal cord degeneration, and cerebellar involvement is much less well characterized. However, some of the cardinal clinical features of ALS, such as dysarthria, dysphagia, gait impairment, falls, and impaired dexterity, are believed to be exacerbated by coexisting cerebellar pathology. Cerebellar pathology may also contribute to cognitive, behavioral, and pseudobulbar manifestations. Our objective was to systematically assess both intracerebellar pathology and cerebrocerebellar connectivity alterations in a genetically stratified cohort of ALS.

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hal-04772811 , version 1 (12-11-2024)

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Marlene Tahedl, Ee Ling Tan, Jana Kleinerova, Siobhan Delaney, Jennifer Hengeveld, et al.. Progressive Cerebrocerebellar Uncoupling in Sporadic and Genetic Forms of Amyotrophic Lateral Sclerosis. Neurology, 2024, 103 (2), pp.e209623. ⟨10.1212/WNL.0000000000209623⟩. ⟨hal-04772811⟩
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