<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04772811</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-20T03:18:47+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Progressive Cerebrocerebellar Uncoupling in Sporadic and Genetic Forms of Amyotrophic Lateral Sclerosis</title>
            <author role="aut">
              <persName>
                <forename type="first">Marlene</forename>
                <surname>Tahedl</surname>
              </persName>
              <idno type="halauthorid">2277976-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ee Ling</forename>
                <surname>Tan</surname>
              </persName>
              <idno type="halauthorid">3289335-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jana</forename>
                <surname>Kleinerova</surname>
              </persName>
              <idno type="halauthorid">3285196-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Siobhan</forename>
                <surname>Delaney</surname>
              </persName>
              <idno type="halauthorid">3285197-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jennifer</forename>
                <surname>Hengeveld</surname>
              </persName>
              <idno type="idhal" notation="numeric">1436380</idno>
              <idno type="halauthorid" notation="string">3289336-1436380</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1615-324X</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mark</forename>
                <surname>Doherty</surname>
              </persName>
              <idno type="idhal" notation="numeric">1436381</idno>
              <idno type="halauthorid" notation="string">2695572-1436381</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7423-4606</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Russell</forename>
                <surname>Mclaughlin</surname>
              </persName>
              <idno type="idhal" notation="numeric">1215627</idno>
              <idno type="halauthorid" notation="string">1535157-1215627</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3915-2135</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre-Francois</forename>
                <surname>Pradat</surname>
              </persName>
              <idno type="halauthorid">437210-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Cédric</forename>
                <surname>Raoul</surname>
              </persName>
              <idno type="halauthorid">249297-0</idno>
              <affiliation ref="#struct-1100672"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fabrice</forename>
                <surname>Ango</surname>
              </persName>
              <idno type="halauthorid">7289-0</idno>
              <affiliation ref="#struct-1100672"/>
              <affiliation ref="#struct-441569"/>
              <affiliation ref="#struct-1100589"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Orla</forename>
                <surname>Hardiman</surname>
              </persName>
              <idno type="idhal" notation="numeric">764481</idno>
              <idno type="halauthorid" notation="string">555434-764481</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2610-1291</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Kai Ming</forename>
                <surname>Chang</surname>
              </persName>
              <idno type="halauthorid">3289337-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jasmin</forename>
                <surname>Lope</surname>
              </persName>
              <idno type="halauthorid">2277978-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Peter</forename>
                <surname>Bede</surname>
              </persName>
              <idno type="halauthorid">555430-0</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Fabrice</forename>
                <surname>Ango</surname>
              </persName>
              <email type="md5">f430f2d71159263d94680aed7a83e276</email>
              <email type="domain">inserm.fr</email>
            </editor>
            <funder ref="#projanr-61364"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2024-11-12 16:11:28</date>
              <date type="whenModified">2025-11-14 16:56:02</date>
              <date type="whenReleased">2024-11-15 16:58:28</date>
              <date type="whenProduced">2024-07-23</date>
              <date type="whenEndEmbargoed">2024-11-12</date>
              <ref type="file" target="https://hal.science/hal-04772811v1/document">
                <date notBefore="2024-11-12"/>
              </ref>
              <ref type="file" subtype="publisherPaid" n="1" target="https://hal.science/hal-04772811v1/file/kleinerova-et-al-2024-progressive-cerebrocerebellar-uncoupling-in-sporadic-and-genetic-forms-of-amyotrophic-lateral.pdf" id="file-4778311-4160742">
                <date notBefore="2024-11-12"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="826343">
                <persName>
                  <forename>Fabrice</forename>
                  <surname>Ango</surname>
                </persName>
                <email type="md5">f430f2d71159263d94680aed7a83e276</email>
                <email type="domain">inserm.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04772811</idno>
            <idno type="halUri">https://hal.science/hal-04772811</idno>
            <idno type="halBibtex">tahedl:hal-04772811</idno>
            <idno type="halRefHtml">&lt;i&gt;Neurology&lt;/i&gt;, 2024, 103 (2), pp.e209623. &lt;a target="_blank" href="https://dx.doi.org/10.1212/WNL.0000000000209623"&gt;&amp;#x27E8;10.1212/WNL.0000000000209623&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Neurology, 2024, 103 (2), pp.e209623. &amp;#x27E8;10.1212/WNL.0000000000209623&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by-nc/4.0/">CC BY-NC 4.0 - Attribution - Non-commercial use<ref corresp="#file-4778311-4160742"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INM">Institut des Neurosciences de Montpellier – Déficits Sensoriels et Moteurs</idno>
            <idno type="stamp" n="UNIV-MONTPELLIER">Université de Montpellier</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="UM-2015-2021" corresp="UNIV-MONTPELLIER">Université de Montpellier (2015-2021)</idno>
            <idno type="stamp" n="UM-EPE" corresp="UNIV-MONTPELLIER">Université de Montpellier - EPE</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Progressive Cerebrocerebellar Uncoupling in Sporadic and Genetic Forms of Amyotrophic Lateral Sclerosis</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Marlene</forename>
                    <surname>Tahedl</surname>
                  </persName>
                  <idno type="halauthorid">2277976-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ee Ling</forename>
                    <surname>Tan</surname>
                  </persName>
                  <idno type="halauthorid">3289335-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jana</forename>
                    <surname>Kleinerova</surname>
                  </persName>
                  <idno type="halauthorid">3285196-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Siobhan</forename>
                    <surname>Delaney</surname>
                  </persName>
                  <idno type="halauthorid">3285197-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jennifer</forename>
                    <surname>Hengeveld</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1436380</idno>
                  <idno type="halauthorid" notation="string">3289336-1436380</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1615-324X</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mark</forename>
                    <surname>Doherty</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1436381</idno>
                  <idno type="halauthorid" notation="string">2695572-1436381</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7423-4606</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Russell</forename>
                    <surname>Mclaughlin</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1215627</idno>
                  <idno type="halauthorid" notation="string">1535157-1215627</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3915-2135</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre-Francois</forename>
                    <surname>Pradat</surname>
                  </persName>
                  <idno type="halauthorid">437210-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Cédric</forename>
                    <surname>Raoul</surname>
                  </persName>
                  <idno type="halauthorid">249297-0</idno>
                  <affiliation ref="#struct-1100672"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fabrice</forename>
                    <surname>Ango</surname>
                  </persName>
                  <idno type="halauthorid">7289-0</idno>
                  <affiliation ref="#struct-1100672"/>
                  <affiliation ref="#struct-441569"/>
                  <affiliation ref="#struct-1100589"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Orla</forename>
                    <surname>Hardiman</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">764481</idno>
                  <idno type="halauthorid" notation="string">555434-764481</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2610-1291</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Kai Ming</forename>
                    <surname>Chang</surname>
                  </persName>
                  <idno type="halauthorid">3289337-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jasmin</forename>
                    <surname>Lope</surname>
                  </persName>
                  <idno type="halauthorid">2277978-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Peter</forename>
                    <surname>Bede</surname>
                  </persName>
                  <idno type="halauthorid">555430-0</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">17388</idno>
                <idno type="issn">0028-3878</idno>
                <idno type="eissn">1526-632X</idno>
                <title level="j">Neurology</title>
                <imprint>
                  <publisher>American Academy of Neurology</publisher>
                  <biblScope unit="volume">103</biblScope>
                  <biblScope unit="issue">2</biblScope>
                  <biblScope unit="pp">e209623</biblScope>
                  <date type="datePub">2024-07-23</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1212/WNL.0000000000209623</idno>
              <idno type="pubmed">38900989</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Amyotrophic Lateral Sclerosis</classCode>
              <classCode scheme="mesh">Magnetic Resonance Imaging</classCode>
              <classCode scheme="mesh">Disease Progression</classCode>
              <classCode scheme="mesh">Cerebral Cortex</classCode>
              <classCode scheme="mesh">Adult</classCode>
              <classCode scheme="mesh">Longitudinal Studies</classCode>
              <classCode scheme="mesh">Male</classCode>
              <classCode scheme="mesh">Female</classCode>
              <classCode scheme="mesh">Middle Aged</classCode>
              <classCode scheme="mesh">Cerebellum</classCode>
              <classCode scheme="mesh">Aged</classCode>
              <classCode scheme="mesh">C9orf72 Protein</classCode>
              <classCode scheme="mesh">Prospective Studies</classCode>
              <classCode scheme="mesh">Ataxin-2</classCode>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Amyotrophic lateral sclerosis (ALS) is predominantly associated with motor cortex, corticospinal tract (CST), brainstem, and spinal cord degeneration, and cerebellar involvement is much less well characterized. However, some of the cardinal clinical features of ALS, such as dysarthria, dysphagia, gait impairment, falls, and impaired dexterity, are believed to be exacerbated by coexisting cerebellar pathology. Cerebellar pathology may also contribute to cognitive, behavioral, and pseudobulbar manifestations. Our objective was to systematically assess both intracerebellar pathology and cerebrocerebellar connectivity alterations in a genetically stratified cohort of ALS.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1100672" status="VALID">
          <idno type="IdRef">139211276</idno>
          <idno type="ISNI">0000000404503123</idno>
          <idno type="RNSR">200316288W</idno>
          <idno type="ROR">https://ror.org/0428ctr80</idno>
          <orgName>Institut des Neurosciences de Montpellier</orgName>
          <orgName type="acronym">INM</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>Hôpital Saint Eloi - Bâtiment INM - 80, rue Augustin Fliche - BP 74103 - 34091 Montpellier cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inmfrance.com/</ref>
          </desc>
          <listRelation>
            <relation name="U 1298" active="#struct-303623" type="direct"/>
            <relation active="#struct-1100589" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1100589" status="VALID">
          <idno type="ROR">https://ror.org/051escj72</idno>
          <orgName>Université de Montpellier</orgName>
          <orgName type="acronym">UM</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.umontpellier.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-61364" status="VALID">
          <idno type="anr">ANR-22-CE17-0003</idno>
          <orgName>CEREBRALS</orgName>
          <desc>Contribution et potentiel thérapeutique du cervelet dans la sclérose latérale amyotrophique</desc>
          <date type="start">2022</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>