Toll-like receptor 4 – a multifunctional virus recognition receptor - Archive ouverte HAL
Article Dans Une Revue (Article De Synthèse) Trends in Microbiology Année : 2024

Toll-like receptor 4 – a multifunctional virus recognition receptor

Résumé

Since the initial description of Toll receptors in Drosophila and their mammalian counterparts Toll-like receptors (TLRs), numerous fundamental and applied studies have explored their crucial role as sensors of pathogen-associated molecular patterns (PAMPs). Among the ten human TLRs, TLR4 is particularly well known for its ability to detect lipopolysaccharides (LPS), a component of the Gram-negative bacterial cell wall. In addition to its archetypal functions, TLR4 is also a versatile virus sensor. This review provides a background on the discovery of TLR4 and how this knowledge laid a foundation for characterization of its diverse roles in antiviral responses, examined through genetic, biochemical, structural, and immunological approaches. These advances have led to a deeper understanding of the molecular functions that enable TLR4 to orchestrate multi-nodal control by professional antigen-presenting cells (APCs) to initiate appropriate and regulated antiviral immune responses.
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Dates et versions

hal-04732416 , version 1 (11-10-2024)

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Elina Gerber-Tichet, Fabien P Blanchet, Karim Majzoub, Eric J Kremer. Toll-like receptor 4 – a multifunctional virus recognition receptor. Trends in Microbiology, In press, ⟨10.1016/j.tim.2024.07.001⟩. ⟨hal-04732416⟩
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