Synthesis of enantiomerically pure (3R,4R,5R)-4-hydroxy isoleucine lactone
Résumé
A short four-step synthesis of (3R,4R,5R)-4-hydroxyisoleucine lactone with total control of stereochemistry is reported, the key intermediate being the didehydroamino acid derivative arising from an aldol dehydration reaction between a glycine anion equivalent and butan-2,3-dione.
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