Noninvasive quantification of elastic anisotropy factor by steered ultrasound pushing beams: towards a novel imaging biomarker of muscle health - Archive ouverte HAL Accéder directement au contenu
Communication Dans Un Congrès Année : 2023

Noninvasive quantification of elastic anisotropy factor by steered ultrasound pushing beams: towards a novel imaging biomarker of muscle health

Résumé

Muscular diseases such as Duchenne muscular dystrophy (DMD) lack reliable biomarkers for disease progression and response to therapies. Tissue mechanical properties are vital for the structure and function of human physiological systems, and often reflect pathophysiological conditions. Ultrasound shear wave elastography (SWE) is an approach that uses focused pushing beams to generate shear waves and employs ultrafast ultrasound imaging to visualize and quantify shear wave propagation in biological soft tissues. In isotropic tissues like the liver, shear wave propagation is governed by tissue elasticity such that wave speed provides an accurate estimate of the shear modulus and, by extension, the Young’s modulus – the most relevant measure of stiffness of a material. However, muscles exhibit significant anisotropy across multiple scales, with muscle fibers typically displaying a pennation angle. Collectively these factors influence wave propagation and the accurate muscle elasticity quantification, rendering its clinical applicability challenging. Here, we introduce an application of SWE that employs a novel steered pushing beam method in conjunction with ultrafast imaging beamformed along the steered pushing beams. We integrated this innovative approach into a commercial ultrasound scanner, making it possible to quantify new biomechanical markers such as in-plane muscle shear modulus and the elastic anisotropy factor – a promising indicator of muscle structural integrity. We first demonstrated the feasibility and validation of this approach using in vitro phantoms and ex vivo fusiform beef muscles. Further ex vivo validation was performed using tensile mechanical testing in pig fusiform muscles. We then applied this technique in vivo to assess, for the first time, the in-plane muscle shear modulus of pennate muscles and their anisotropy factor under different tensile muscle (active and passive) states in healthy humans. Finally, we performed preliminary tests on patients with DMD. This study highlights a translational proof of concept for a novel SWE approach, offering real-time quantification of new noninvasive mechanical variables with potential for monitoring neuromuscular diseases affecting tissue biomechanics. Further research is required to investigate the clinical value of these biophysical parameters.
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Dates et versions

hal-04624366 , version 1 (01-07-2024)

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  • HAL Id : hal-04624366 , version 1

Citer

Ricardo J. Andrade, Ha Hien Phuong Ngo, Javier Brum, Nicolas Benech, S. Chatelin, et al.. Noninvasive quantification of elastic anisotropy factor by steered ultrasound pushing beams: towards a novel imaging biomarker of muscle health. 20èmes Journées de la Société Française de Myologie (SFM), Nov 2023, La Baule (France), France. ⟨hal-04624366⟩
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