The genus Serratia revisited by genomics - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Nature Communications Année : 2022

The genus Serratia revisited by genomics

Kerry Pettigrew
Matthew Holden

Résumé

The genus Serratia has been studied for over a century and includes clinically-important and diverse environmental members. Despite this, there is a paucity of genomic information across the genus and a robust whole genome-based phylogenetic framework is lacking. Here, we have assembled and analysed a representative set of 664 genomes from across the genus, including 215 historic isolates originally used in defining the genus. Phylogenomic analysis of the genus reveals a clearly-defined population structure which displays deep divisions and aligns with ecological niche, as well as striking congruence between historical biochemical phenotyping data and contemporary genomics data. We highlight the genomic, phenotypic and plasmid diversity of Serratia , and provide evidence of different patterns of gene flow across the genus. Our work provides a framework for understanding the emergence of clinical and other lineages of Serratia .
Fichier principal
Vignette du fichier
s41467-022-32929-2.pdf (2.84 Mo) Télécharger le fichier
Origine Publication financée par une institution
Licence

Dates et versions

hal-04613466 , version 1 (17-06-2024)

Licence

Identifiants

Citer

David Williams, Patrick Grimont, Adrián Cazares, Francine Grimont, Elisabeth Ageron, et al.. The genus Serratia revisited by genomics. Nature Communications, 2022, 13 (1), pp.5195. ⟨10.1038/s41467-022-32929-2⟩. ⟨hal-04613466⟩
14 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More