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Article Dans Une Revue International Journal of Nanomedicine Année : 2015

Photoactive TiO2 antibacterial coating on surgical external fixation pins for clinical application

Résumé

External fixation is a method of osteosynthesis currently used in traumatology and orthopedic surgery. Pin tract infection is a common problem in clinical practice. Infection occurs after bacterial colonization of the pin due to its contact with skin and the local environment. One way to prevent such local contamination is to create a specific coating that could be applied in the medical field. In this work, we developed a surface coating for external fixator pins based on the photocatalytic properties of titanium dioxide, producing a bactericidal effect with sufficient mechanical strength to be compatible with surgical use. The morphology and structure of the sol-gel coating layers were characterized using, respectively, scanning electron microscopy and X-ray diffraction. The resistance properties of the coating were investigated by mechanical testing. Photodegradation of acid orange 7 in aqueous solution was used as a probe to assess the photocatalytic activity of the titanium dioxide layers under ultraviolet irradiation. The bactericidal effect induced by the process was evaluated against two strains, ie, Staphylococcus aureus and multiresistant Staphylococcus epidermidis. The coated pins showed good mechanical strength and an efficient antibacterial effect after 1 hour of ultraviolet irradiation.
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Dates et versions

hal-04601906 , version 1 (05-06-2024)

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Guillaume Villatte, Christophe Massard, Stéphane Descamps, Yves Sibaud, Christiane Forestier, et al.. Photoactive TiO2 antibacterial coating on surgical external fixation pins for clinical application. International Journal of Nanomedicine, 2015, 10 (1), pp.3367-3375. ⟨10.2147/IJN.S81518⟩. ⟨hal-04601906⟩
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