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Article Dans Une Revue FEMS Microbiology Reviews Année : 2020

Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations

Samira Soltani
  • Fonction : Auteur
Riadh Hammami
Paul D Cotter
  • Fonction : Auteur
Sylvie Rebuffat
  • Fonction : Auteur
Laila Ben Said
  • Fonction : Auteur
Hélène Gaudreau
  • Fonction : Auteur
François Bédard
  • Fonction : Auteur
Eric Biron
  • Fonction : Auteur
Ismail Fliss
  • Fonction : Auteur
  • PersonId : 1276416

Résumé

ABSTRACT In recent decades, bacteriocins have received substantial attention as antimicrobial compounds. Although bacteriocins have been predominantly exploited as food preservatives, they are now receiving increased attention as potential clinical antimicrobials and as possible immune-modulating agents. Infections caused by antibiotic-resistant bacteria have been declared as a global threat to public health. Bacteriocins represent a potential solution to this worldwide threat due to their broad- or narrow-spectrum activity against antibiotic-resistant bacteria. Notably, despite their role in food safety as natural alternatives to chemical preservatives, nisin remains the only bacteriocin legally approved by regulatory agencies as a food preservative. Moreover, insufficient data on the safety and toxicity of bacteriocins represent a barrier against the more widespread use of bacteriocins by the food and medical industry. Here, we focus on the most recent trends relating to the application of bacteriocins, their toxicity and impacts.
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hal-04549712 , version 1 (17-04-2024)

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Samira Soltani, Riadh Hammami, Paul D Cotter, Sylvie Rebuffat, Laila Ben Said, et al.. Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations. FEMS Microbiology Reviews, 2020, 45 (1), ⟨10.1093/femsre/fuaa039⟩. ⟨hal-04549712⟩
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