Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations
Résumé
ABSTRACT In recent decades, bacteriocins have received substantial attention as antimicrobial compounds. Although bacteriocins have been predominantly exploited as food preservatives, they are now receiving increased attention as potential clinical antimicrobials and as possible immune-modulating agents. Infections caused by antibiotic-resistant bacteria have been declared as a global threat to public health. Bacteriocins represent a potential solution to this worldwide threat due to their broad- or narrow-spectrum activity against antibiotic-resistant bacteria. Notably, despite their role in food safety as natural alternatives to chemical preservatives, nisin remains the only bacteriocin legally approved by regulatory agencies as a food preservative. Moreover, insufficient data on the safety and toxicity of bacteriocins represent a barrier against the more widespread use of bacteriocins by the food and medical industry. Here, we focus on the most recent trends relating to the application of bacteriocins, their toxicity and impacts.
Mots clés
Antimicrobial activity
gastrointestinal bihaviour and toxicity of bacteriocins antimicrobials bacteriocins gastrointestinal bioavailability toxicity safety evaluation regulations
gastrointestinal bihaviour and toxicity of bacteriocins antimicrobials
bacteriocins
gastrointestinal bioavailability
toxicity
safety evaluation
regulations
Domaines
Sciences du Vivant [q-bio]Origine | Fichiers éditeurs autorisés sur une archive ouverte |
---|