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Article Dans Une Revue Nature Communications Année : 2023

Association between vmPFC gray matter volume and smoking initiation in adolescents

Shitong Xiang
Tianye Jia
Chao Xie
  • Fonction : Auteur
Wei Cheng
  • Fonction : Auteur
Bader Chaarani
  • Fonction : Auteur
Tobias Banaschewski
Gareth Barker
Arun Bokde
Christian Büchel
Sylvane Desrivières
Herta Flor
Antoine Grigis
  • Fonction : Auteur
Penny Gowland
Rüdiger Brühl
Frauke Nees
Dimitri Papadopoulos Orfanos
Luise Poustka
  • Fonction : Auteur
Sarah Hohmann
Juliane Fröhner
Michael Smolka
Nilakshi Vaidya
  • Fonction : Auteur
Henrik Walter
Robert Whelan
  • Fonction : Auteur
Hugh Garavan
  • Fonction : Auteur
Gunter Schumann
Barbara Sahakian
Trevor Robbins
Jianfeng Feng

Résumé

Abstract Smoking of cigarettes among young adolescents is a pressing public health issue. However, the neural mechanisms underlying smoking initiation and sustenance during adolescence, especially the potential causal interactions between altered brain development and smoking behaviour, remain elusive. Here, using large longitudinal adolescence imaging genetic cohorts, we identify associations between left ventromedial prefrontal cortex (vmPFC) gray matter volume (GMV) and subsequent self-reported smoking initiation, and between right vmPFC GMV and the maintenance of smoking behaviour. Rule-breaking behaviour mediates the association between smaller left vmPFC GMV and smoking behaviour based on longitudinal cross-lagged analysis and Mendelian randomisation. In contrast, smoking behaviour associated longitudinal covariation of right vmPFC GMV and sensation seeking (especially hedonic experience) highlights a potential reward-based mechanism for sustaining addictive behaviour. Taken together, our findings reveal vmPFC GMV as a possible biomarker for the early stages of nicotine addiction, with implications for its prevention and treatment.

Dates et versions

hal-04471072 , version 1 (21-02-2024)

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Shitong Xiang, Tianye Jia, Chao Xie, Wei Cheng, Bader Chaarani, et al.. Association between vmPFC gray matter volume and smoking initiation in adolescents. Nature Communications, 2023, 14 (1), pp.4684. ⟨10.1038/s41467-023-40079-2⟩. ⟨hal-04471072⟩
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