Association between vmPFC gray matter volume and smoking initiation in adolescents - Archive ouverte HAL
Article Dans Une Revue Nature Communications Année : 2023

Association between vmPFC gray matter volume and smoking initiation in adolescents

Shitong Xiang
Gareth Barker
Arun Bokde
Sylvane Desrivières
Penny Gowland

Résumé

Abstract Smoking of cigarettes among young adolescents is a pressing public health issue. However, the neural mechanisms underlying smoking initiation and sustenance during adolescence, especially the potential causal interactions between altered brain development and smoking behaviour, remain elusive. Here, using large longitudinal adolescence imaging genetic cohorts, we identify associations between left ventromedial prefrontal cortex (vmPFC) gray matter volume (GMV) and subsequent self-reported smoking initiation, and between right vmPFC GMV and the maintenance of smoking behaviour. Rule-breaking behaviour mediates the association between smaller left vmPFC GMV and smoking behaviour based on longitudinal cross-lagged analysis and Mendelian randomisation. In contrast, smoking behaviour associated longitudinal covariation of right vmPFC GMV and sensation seeking (especially hedonic experience) highlights a potential reward-based mechanism for sustaining addictive behaviour. Taken together, our findings reveal vmPFC GMV as a possible biomarker for the early stages of nicotine addiction, with implications for its prevention and treatment.
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hal-04471072 , version 1 (09-09-2024)

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Shitong Xiang, Tianye Jia, Chao Xie, Wei Cheng, Bader Chaarani, et al.. Association between vmPFC gray matter volume and smoking initiation in adolescents. Nature Communications, 2023, 14 (1), pp.4684. ⟨10.1038/s41467-023-40079-2⟩. ⟨hal-04471072⟩
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