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Article Dans Une Revue Journal of Vascular Access Année : 2020

Managing chemotherapy extravasation in totally implantable central venous access: Use of subcutaneous wash-out technique

Abdelkader Taibi
Sylvia Bardet M
Elise Deluche
  • Fonction : Auteur
Fabien Fredon
  • Fonction : Auteur
Niki Christou
  • Fonction : Auteur
Julie Usseglio
  • Fonction : Auteur
Muriel Mathonnet
  • Fonction : Auteur

Résumé

Background: Totally implanted venous access is widely used in chemotherapy administration. With over 1 million intravenous chemotherapy infusions given worldwide each day, complications are frequent. Accidental cases of extravasation in the presence of a catheter are rare yet very serious and may require discontinuation of chemotherapy. The aim of this study was to evaluate the feasibility and efficacy of the subcutaneous wash-out technique for chemotherapy extravasation treatment. Methods: We retrospectively reviewed the medical charts of patients who had received chemotherapy and sustained extravasation in our hospital between October 2013 and October 2016. Subcutaneous wash-out treatments were carried out exclusively, without the application of antidotes or the use of specific antidotes. Results: We documented seven cases of chemotherapy extravasation. Two cases were treated with antidotes and suffered necrosis in the following weeks. The five patients treated using subcutaneous wash-out had no necrosis and had a steady decrease in the inflammatory reaction of the cutaneous and subcutaneous soft tissues. For these five patients, chemotherapy was restarted within 1 month following extravasation. Conclusion: This study would argue for the feasibility and effectiveness of subcutaneous wash-out in the treatment of chemotherapy extravasations.
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Dates et versions

hal-04448581 , version 1 (09-02-2024)

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Abdelkader Taibi, Sylvia Bardet M, Sylvaine Durand Fontanier, Elise Deluche, Fabien Fredon, et al.. Managing chemotherapy extravasation in totally implantable central venous access: Use of subcutaneous wash-out technique. Journal of Vascular Access, 2020, 21 (5), pp.723-731. ⟨10.1177/1129729820905174⟩. ⟨hal-04448581⟩
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