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Article Dans Une Revue Chemical Science Année : 2021

The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms

Mahmudul Hasan
Lotta Happonen
Anders Sundin
Johan Unge
Johan Malmström
Gunilla Westergren-Thorsson
Ulf Ellervik
Anders Malmström
Emil Tykesson

Résumé

Structural studies of human DS-epi1 suggests a new catalytic isomerization mechanism and reveals remarkable similarities to bacterial proteins.

Dates et versions

hal-04429650 , version 1 (31-01-2024)

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Citer

Mahmudul Hasan, Hamed Khakzad, Lotta Happonen, Anders Sundin, Johan Unge, et al.. The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms. Chemical Science, 2021, 12 (5), pp.1869-1885. ⟨10.1039/D0SC05971D⟩. ⟨hal-04429650⟩
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