Different Genetic Signatures of Small‐Cell Lung Cancer Characterize Anti‐GABABR and Anti‐Hu Paraneoplastic Neurological Syndromes
Alberto Vogrig
(1, 2, 3)
,
Antoine Pegat
(2, 4)
,
Macarena Villagrán‐garcía
(2, 1)
,
Valentin Wucher
(2, 1)
,
Valéry Attignon
(5)
,
Emilie Sohier
(6, 5)
,
Marie Brevet
(2)
,
Veronique Rogemond
(2, 1)
,
Anne‐laurie Pinto
(2, 1)
,
Sergio Muñiz‐castrillo
(2, 1, 7)
,
Elise Peter
(2, 1)
,
Melisse Robert
(2, 1)
,
Géraldine Picard
(2, 1)
,
Lucie Hopes
(8)
,
Dimitri Psimaras
(9, 10)
,
Anthony Terra
(2)
,
Corinne Perrin
(2)
,
Dominique Cogne
(5)
,
Severine Tabone‐eglinger
(5)
,
Séverine Martinez
(5)
,
Delphine Jury
(5)
,
Julie Valantin
(5)
,
Nicolas Gadot
(5)
,
Jessie Auclair‐perrossier
(5)
,
Alain Viari
(5, 6)
,
Bertrand Dubois
(5)
,
Virginie Desestret
(2, 1)
,
Jérôme Honnorat
(2, 1)
1
MeLiS -
Mécanismes en sciences intégratives du vivant
2 HCL - Hospices Civils de Lyon
3 Ospedale "Santa Maria della Misericordia" = University Hospital "Santa Maria della Misericordia"
4 INMG-AR - Institut NeuroMyoGène - Appui à la recherche
5 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
6 Synergie Lyon Cancer-Platform of Bioinformatics-Gilles Thomas
7 Stanford University
8 Service de neurologie [CHRU Nancy]
9 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
10 SU - Sorbonne Université
2 HCL - Hospices Civils de Lyon
3 Ospedale "Santa Maria della Misericordia" = University Hospital "Santa Maria della Misericordia"
4 INMG-AR - Institut NeuroMyoGène - Appui à la recherche
5 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
6 Synergie Lyon Cancer-Platform of Bioinformatics-Gilles Thomas
7 Stanford University
8 Service de neurologie [CHRU Nancy]
9 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
10 SU - Sorbonne Université
Antoine Pegat
- Fonction : Auteur
- PersonId : 1337109
- ORCID : 0000-0003-1563-9432
Sergio Muñiz‐castrillo
- Fonction : Auteur
- PersonId : 806924
- ORCID : 0000-0001-5958-3288
Elise Peter
- Fonction : Auteur
- PersonId : 1337110
- ORCID : 0000-0002-7898-8069
Alain Viari
- Fonction : Auteur
- PersonId : 18170
- IdHAL : alain-viari
- ORCID : 0000-0002-1329-7777
- IdRef : 081478151
Bertrand Dubois
- Fonction : Auteur
- PersonId : 1339563
- IdHAL : bertranddubois
- ORCID : 0000-0002-7859-4975
Jérôme Honnorat
- Fonction : Auteur
- PersonId : 839407
Résumé
Objective: Small-cell lung cancer (SCLC) is the malignancy most frequently associated with paraneoplastic neurological syndromes (PNS) and can trigger different antibody responses against intracellular (Hu) or neuronal surface (GABA B R) antigens. Our aim was to clarify whether the genomic and transcriptomic features of SCLC are different in patients with anti-GABA B R or anti-Hu PNS compared with SCLC without PNS. Methods: A total of 76 SCLC tumor samples were collected: 34 anti-Hu, 14 anti-GABA B R, and 28 SCLC without PNS. The study consisted of 4 steps: (1) pathological confirmation; (2) next generation sequencing using a panel of 98 genes,