Different Genetic Signatures of Small‐Cell Lung Cancer Characterize <scp>Anti‐GABA<sub>B</sub>R</scp> and <scp>Anti‐Hu</scp> Paraneoplastic Neurological Syndromes - Archive ouverte HAL Access content directly
Journal Articles Annals of Neurology Year : 2023

Different Genetic Signatures of Small‐Cell Lung Cancer Characterize Anti‐GABABR and Anti‐Hu Paraneoplastic Neurological Syndromes

Abstract

Objective: Small-cell lung cancer (SCLC) is the malignancy most frequently associated with paraneoplastic neurological syndromes (PNS) and can trigger different antibody responses against intracellular (Hu) or neuronal surface (GABA B R) antigens. Our aim was to clarify whether the genomic and transcriptomic features of SCLC are different in patients with anti-GABA B R or anti-Hu PNS compared with SCLC without PNS. Methods: A total of 76 SCLC tumor samples were collected: 34 anti-Hu, 14 anti-GABA B R, and 28 SCLC without PNS. The study consisted of 4 steps: (1) pathological confirmation; (2) next generation sequencing using a panel of 98 genes,

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Cancer
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Dates and versions

hal-04401076 , version 1 (18-01-2024)

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Alberto Vogrig, Antoine Pegat, Macarena Villagrán‐garcía, Valentin Wucher, Valéry Attignon, et al.. Different Genetic Signatures of Small‐Cell Lung Cancer Characterize Anti‐GABABR and Anti‐Hu Paraneoplastic Neurological Syndromes. Annals of Neurology, 2023, 94 (6), pp.1102 - 1115. ⟨10.1002/ana.26784⟩. ⟨hal-04401076⟩
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